Current management of relapsing-remitting multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Treatment of relapsing-remitting multiple sclerosis: current and future algorithms.
term outcomes. A long-term study examined survival in a cohort of patients (n = 372) who had participated in a pivotal randomized, placebo-controlled clinical trial of interferon beta in relapsing-remitting MS [5] . After a median of 21.1 years from the time of enrollment, 98% of patients were identified and 81 deaths were recorded. Early treatment was associated with prolonged survival, as evi...
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BACKGROUND Recombinant interferons have been shown to suppress both the clinical and magnetic resonance imaging (MRI) measures of disease activity in patients with relapsing remitting multiple sclerosis (RRMS). OBJECTIVES We performed a Cochrane review of all randomised, placebo-controlled trials of recombinant interferons in RRMS. SEARCH STRATEGY Of 208 articles identified by a predefined ...
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OBJECTIVE To define the extent of neuronal injury and loss in thalamic gray matter in patients with relapsing-remitting (RR) MS and to characterize how these neuronal pathologic changes are related to disease duration. METHODS The authors studied 14 patients with RRMS (Expanded Disability Status Scale score, mean 3.25, range 2.0 to 6.0) and 14 (8 men, 6 women) age-matched healthy controls. St...
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Natalizumab is the first humanized moclonal antibody indicated in the treatment of relapsing-remitting multiple sclerosis (RRMS). Based on its remarkable efficacy in reducing disease activity and reducing the risk of disability progession in RRMS, and the risk of a serious adverse event (progressive multifocal leukoencephalopathy [PML]), natalizumab was indicated in active RRMS, mostly as a sec...
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In the past 10 years, the treatment options for patients with relapsing-remitting multiple sclerosis (RRMS) underwent some major changes. After relying on injectable interferon-beta preparations for quite some time, the advent of the first monoclonal antibody, natalizumab, followed by the first oral drug, fingolimod, improved the outcome of these patients and the possibilities to treat them mor...
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ژورنال
عنوان ژورنال: Internal Medicine Journal
سال: 2014
ISSN: 1444-0903
DOI: 10.1111/imj.12558